N-methyl Protoporphyrin IX

N-methyl Protoporphyrin IX is a transition state analog that potently inhibits protoporphyrin IX ferrochelatase (Ki = 10 nM), blocking the terminal step of the heme biosynthetic pathway. It is used to study the effect of heme synthesis blockade in cell systems.Formal Name: 7,12-diethenyl-3,8,13,17,23-pentamethyl-21H,23H-porphine-2,18-dipropanoic acid. CAS Number: 79236-56-9. Synonyms: NMPP, N-methyl PPIX. Molecular Formula: C35H36N4O4. Formula Weight: 576.7. Purity: >95% (a mixture of isomers). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.17 mg/ml, DMSO: 15 mg/ml. lambdamax: 211, 303, 401, 573 nm. SMILES: CC1=C2[NH]C(/C=C(C(CCC(O)=O)=C3C)\[N]=C3/C=C4[N](C)/C(C(C=C)=C\4C)=C\C5=[N]/C(C(C=C)=C5C)=C\2)=C1CCC(O)=O. InChi Code: InChI=1S/C35H36N4O4/c1-8-22-18(3)28-17-33-23(9-2)21(6)32(39(33)7)16-27-20(5)25(11-13-35(42)43)31(38-27)15-30-24(10-12-34(40)41)19(4)26(36-30)14-29(22)37-28/h8-9,14-17,36H,1-2,10-13H2,3-7H3,(H,40,41)(H,42,43)/b26-14-,27-16-,28-17-,29-14-,30-15-,31-15-. InChi Key: UMUAJMDAFLPQGQ-YIYRCNGCSA-N.