N-Desethylamiodarone (hydrochloride)

Amiodarone (Cay-15213) is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM. In humans, cytochrome P450 3A is involved in the metabolism of amiodarone. N-Desethylamiodarone is the major, active metabolite of amiodarone. This compound has been used as an analytical reference standard for quantifying amiodarone in plasma samples.Formal Name: (2-butyl-3-benzofuranyl)[4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl]-methanone, monohydrochloride. CAS Number: 96027-74-6. Molecular Formula: C23H25I2NO3 . HCl. Formula Weight: 653.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml. lambdamax: 242 nm. SMILES: CCCCC1=C(C(C2=CC(I)=C(OCCNCC)C(I)=C2)=O)C3=CC=CC=C3O1.Cl. InChi Code: InChI=1S/C23H25I2NO3.ClH/c1-3-5-9-20-21(16-8-6-7-10-19(16)29-20)22(27)15-13-17(24)23(18(25)14-15)28-12-11-26-4-2,/h6-8,10,13-14,26H,3-5,9,11-12H2,1-2H3,1H. InChi Key: OCQPMJVGWGJLLG-UHFFFAOYSA-N.