N-Acetyltyramine

Description: N-Acetyltyramine is the active compound extracted from a fermentation broth of strain M3-10 which produces quorum-sensing inhibitor (QSI) compound. N-Acetyltyramine inhibits Chromobacterium violaceum ATCC 12472 violacein production and virulence factors, such as pyoverdine production, as well as swarming and twitching motilities, produced by Pseudomonas aeruginosa PAO1. Target: Antibacterial. Smiles: CC(=O)NCCc1ccc(O)cc1. References: Kunimoto S, et al. Reversal of resistance by N-acetyltyramine or N-acetyl-2-phenylethylamine in doxorubicin-resistant leukemia P388 cells. J Antibiot (Tokyo). 1987,40(11):1651-1652.