N-Acetyl-DL-penicillamine

N-Acetyl-DL-penicillamine is a chelating agent. It inhibits the binding of methyl mercury to isolated human erythrocytes by 50% and removes 50% of methyl mercury ions from methyl mercury-loaded blood cells when used at a concentration of 1 mM. N-Acetyl-DL-penicillamine (3 mmol/kg per day, p.o.) reduces the biological half-life of mercury and decreases liver, kidney, brain, and blood mercury levels, as well as increases urinary excretion of mercury in a concentration-dependent manner, in mice when administered following injection of methyl mercuric chloride. It decreases mercuric chloride-induced mortality in mice when administered orally at a dose of 1.6 mmol/kg. N-Acetyl-DL-penicillamine is also an analog of SNAP (Cay-82250) that does not generate nitric oxide and has been used as a negative control in experiments using SNAP.Formal Name: N-acetyl-3-mercapto-valine. CAS Number: 59-53-0. Synonyms: NAPA, NSC 28039, NSC 92752. Molecular Formula: C7H13NO3S. Formula Weight: 191.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml, Ethanol: 5 mg/ml. SMILES: SC(C)(C)C(NC(C)=O)C(O)=O. InChi Code: InChI=1S/C7H13NO3S/c1-4(9)8-5(6(10)11)7(2,3)12/h5,12H,1-3H3,(H,8,9)(H,10,11). InChi Key: MNNBCKASUFBXCO-UHFFFAOYSA-N.