N-acetyl-5-Aminosalicylic Acid

N-acetyl-5-Aminosalicylic acid is a metabolite of the anti-inflammatory agent 5-aminosalicylic acid (5-ASA, Cay-70265) and its prodrug form, sulfasalazine (Cay-15025). It is formed in the liver, intestinal lumen, and colonic epithelial cells via N-acetyltransferases. It reduces IFN-gamma binding to colonic epithelial cells by 24% when used at a concentration of 10 mM. N-acetyl-5-Aminosalicylic acid (100 µM) scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals in a cell-free assay and inhibits base hydroxylation in DNA stimulated by hydroxy radicals. Unlike sulfasalazine, N-acetyl-5-aminosalicylic acid does not inhibit 15-hydroxy prostaglandin dehydrogenase (PGDH). Urinary levels of N-acetyl-5-aminosalicylic acid have been used as a marker of 5-ASA adherence in patients with inflammatory bowel disease.Formal Name: 5-(acetylamino)-2-hydroxy-benzoic acid. CAS Number: 51-59-2. Synonyms: Acetylmesalazine, N-acetyl-ASA, N-acetyl Mesalamine, NSC 54183, Salicytamide. Molecular Formula: C9H9NO4. Formula Weight: 195.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: OC1=C(C(O)=O)C=C(NC(C)=O)C=C1. InChi Code: InChI=1S/C9H9NO4/c1-5(11)10-6-2-3-8(12)7(4-6)9(13)14/h2-4,12H,1H3,(H,10,11)(H,13,14). InChi Key: GEFDRROBUCULOD-UHFFFAOYSA-N.