Myxochelin A

Myxochelin A is a microbial metabolite that has been found in A. disciformis and has diverse biological activities. It is active against Gram-positive bacteria, including B. cereus, S. aureus, and M. luteus, but not Gram-negative bacteria or fungi in an agar diffusion assay when used at a concentration of 80 µg/disc. Myxochelin A inhibits 5-lipoxygenase (5-LO) activity with an IC50 value of 1.9 µM for the recombinant human enzyme. It is cytotoxic to 26-L5 colon cancer cells when used at a concentration of 3 µg/ml.Formal Name: N,N'-[(1S)-1-(hydroxymethyl)-1,5-pentanediyl]bis[2,3-dihydroxy-benzamide. CAS Number: 120243-02-9. Synonyms: (S)-Myxochelin A. Molecular Formula: C20H24N2O7. Formula Weight: 404.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: OC1=C(O)C(C(N[C@H](CO)CCCCNC(C2=CC=CC(O)=C2O)=O)=O)=CC=C1. InChi Code: InChI=1S/C20H24N2O7/c23-11-12(22-20(29)14-7-4-9-16(25)18(14)27)5-1-2-10-21-19(28)13-6-3-8-15(24)17(13)26/h3-4,6-9,12,23-27H,1-2,5,10-11H2,(H,21,28)(H,22,29)/t12-/m0/s1. InChi Key: WNBVGSNESTZACV-LBPRGKRZSA-N. Origin: Synthetic.