MW-150

MW-150 is an inhibitor of p38alpha MAPK (Ki = 101 nM). It is 6-, 10-, and 14-fold selective for p38alpha MAPK over the serine/threonine protein kinase NLK, p38beta MAPK, and p38delta MAPK, respectively, and is also selective over the enzymatically normal mutant p38alpha MAPKT106M. It inhibits p38alpha MAPK phosphorylation of the endogenous substrate MAPK-activated protein kinase 2 (MK2) in LPS-activated glia in a concentration-dependent manner and decreases the levels of IL-1beta in the same cells. MW-150 (2.5 mg/kg per day, i.p.) reduces the number of errors made in the spatial reference memory version of the radial arm water maze in aged amyloid precursor protein/presenilin 1 (APP/PS1) knock-in mice as a model of Alzheimer's disease.Formal Name: 6-(4-methyl-1-piperazinyl)-3-(2-naphthalenyl)-4-(4-pyridinyl)-pyridazine. CAS Number: 1628502-91-9. Synonyms: MW01-18-150SRM. Molecular Formula: C24H23N5. Formula Weight: 381.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 15 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml, DMSO: 1 mg/ml, Ethanol: 1 mg/ml. lambdamax: 217, 232, 274 nm. SMILES: CN(CC1)CCN1C2=CC(C3=CC=NC=C3)=C(C4=CC5=C(C=CC=C5)C=C4)N=N2. InChi Code: InChI=1S/C24H23N5/c1-28-12-14-29(15-13-28)23-17-22(19-8-10-25-11-9-19)24(27-26-23)21-7-6-18-4-2-3-5-20(18)16-21/h2-11,16-17H,12-15H2,1H3. InChi Key: CIIVUDIZZJLXCN-UHFFFAOYSA-N.