Muristerone A

Muristerone A is a natural analog of 20-hydroxyecdysone (Cay-16145). It is an agonist of the ecdysteroid receptor (Kd = 1 nM), a nuclear receptor that heterodimerizes with a retinoid X receptor ortholog and regulates arthropod development. Muristerone A is used as an agonist in ecdysone-inducible gene expression systems in mammalian cells. However, it inhibits apoptosis in the human colon carcinoma cell line RKO by inducing the upregulation of Bcl-xL, suggesting limitations in its use in certain types of studies.Formal Name: 2beta,3beta,5beta,11alpha,14,20,22R-heptahydroxy-cholest-7-en-6-one. CAS Number: 38778-30-2. Synonyms: Mur A. Molecular Formula: C27H44O8. Formula Weight: 496.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: CC(C)CC[C@@H](O)[C@](C)(O)[C@@]1([H])CC[C@@]2(O)C3=CC([C@]4(O)C[C@@H](O)[C@@H](O)C[C@]4(C)[C@@]3([H])[C@H](O)C[C@@]21C)=O. InChi Code: InChI=1S/C27H44O8/c1-14(2)6-7-20(31)25(5,33)19-8-9-26(34)15-10-21(32)27(35)13-17(29)16(28)11-24(27,4)22(15)18(30)12-23(19,26)3/h10,14,16-20,22,28-31,33-35H,6-9,11-13H2,1-5H3/t16-,17+,18+,19-,20+,22+,23+,24+,25+,26+,27+/m0/s1. InChi Key: LRJUYAVTHIEHAI-LHBNDURVSA-N. Origin: Plant/Ipomoea hederacea.