MT-1207 (hydrochloride)

MT-1207 is an antagonist of alpha1A-, alpha1B-, and alpha1D-adrenergic receptors and the serotonin (5-HT) receptor subtype 5-HT2A (IC50s = 1A, 5-HT1B, 5-HT2B, and 5-HT2C receptors (IC50s = 18.1, 4.89, 4.68, 41, 11.5, and 26 nM, respectively), among others. MT-1207 induces relaxation of isolated rat aortic rings precontracted with epinephrine, potassium chloride, norepinephrine, or 5-HT in a concentration-dependent manner. It decreases systolic and diastolic blood pressure and heart rate in spontaneously hypertensive rats and two kidney-one clip (2K-1C) renal hypertensive dogs when administered at doses of 10 and 4 mg/kg, respectively.Formal Name: 1-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-1H-benzotriazole, monohydrochloride. CAS Number: 1610794-70-1. Molecular Formula: C21H24N6S . HCl. Formula Weight: 429.0. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble: 0.1-1 mg/ml. SMILES: N1(N=NC2=C1C=CC=C2)CCCCN3CCN(CC3)C4=NSC5=C4C=CC=C5.Cl. InChi Code: InChI=1S/C21H24N6S.ClH/c1-4-10-20-17(7-1)21(23-28-20)26-15-13-25(14-16-26)11-5-6-12-27-19-9-3-2-8-18(19)22-24-27,/h1-4,7-10H,5-6,11-16H2,1H. InChi Key: UFMLXCNESJKXFY-UHFFFAOYSA-N.