MSI-1436

Description: MSI-1436 is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTB1B) with an IC50 of approximately 1 µM. Target: Others. Smiles: O[C@H]1[C@@]2([C@@]([C@]3(C)[C@@](C1)(C[C@@H](NCCCNCCCCN CCCN)CC3)[H])(CC[C@@]4(C)[C@]2(CC[C@@]4([C@@H](CC[C@@H](OS(=O)(=O)O)[C@H](C)C)C)[H])[H])[H])[H]. References: Lantz KA, et al. Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring). 2010 Aug,18(8):1516-1523.