mPGES-1 Inhibitor-1

Description: mPGES-1 Inhibitor-1 is a novel selective inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) with anti-inflammatory and analgesic activity for the study of acute liver injury. Target: Prostaglandin Receptor. Smiles: O=C(NC1=NC=CN1)C2=CC(=CC=C2Cl)CNC(=O)C(C)(C)C. References: Norman BH,et al. Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury. J Med Chem. 2018 Mar 8,61(5):2041-2051.