Moxonidine

Moxonidine is an imidazoline 1 (I1) receptor agonist (Ki = 56 nM in a radioligand binding assay). It is also an agonist of the alpha2A-adrenergic receptor (alpha2A-AR, Ki = 150 nM in a radioligand binding assay). It is selective for I1 and alpha2A-AR receptors over alpha1-, alpha2B, and alpha2C-ARs (Kis = >30,000, 1,000, and 2,000 nM, respectively). Moxonidine decreases mean arterial pressure in spontaneously hypertensive rats when administered at a dose of 0.2 nmol injected into the rostral ventrolateral medulla oblongata (RVLM). It also reduces blood pressure in cynomolgus monkeys when administered at a dose of 167 µg/kg.Formal Name: 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine. CAS Number: 75438-57-2. Synonyms: LY326869. Molecular Formula: C9H12ClN5O. Formula Weight: 241.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 222, 256 nm. SMILES: CC1=NC(Cl)=C(NC2=NCCN2)C(OC)=N1. InChi Code: InChI=1S/C9H12ClN5O/c1-5-13-7(10)6(8(14-5)16-2)15-9-11-3-4-12-9/h3-4H2,1-2H3,(H2,11,12,15). InChi Key: WPNJAUFVNXKLIM-UHFFFAOYSA-N.