Molnupiravir

Molnupiravir is a prodrug form of the antiviral ribonucleoside analog EIDD-1931 (Cay-9002958). Molnupiravir (500 mg/kg) reduces body weight loss, lung hemorrhage, and lung viral titers, as well as improves pulmonary function in mouse models of severe acute respiratory syndrome coronavirus (SARS-CoV) or Middle East respiratory syndrome coronavirus (MERS-CoV) infection when administered prophylactically at 2 hours pre-infection or therapeutically at 12 hours post-infection. It also reduces shed virus load and fever in ferret models of H1N1 or H3N2 influenza A virus infection when administered at a dose of 100 mg/kg twice per day.Formal Name: uridine, 4Z-oxime, 5'-(2-methylpropanoate). CAS Number: 2492423-29-5. Synonyms: EIDD-2801, beta-D-N4-Hydroxycytidine-5'-isopropyl ester, MK-4482. Molecular Formula: C13H19N3O7. Formula Weight: 329.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 235, 276 nm. SMILES: O=C(N/1)N([C@H]2[C@H](O)[C@H](O)[C@@H](COC(C(C)C)=O)O2)C=CC1=N/O. InChi Code: InChI=1S/C13H19N3O7/c1-6(2)12(19)22-5-7-9(17)10(18)11(23-7)16-4-3-8(15-21)14-13(16)20/h3-4,6-7,9-11,17-18,21H,5H2,1-2H3,(H,14,15,20)/t7-,9-,10-,11-/m1/s1. InChi Key: HTNPEHXGEKVIHG-QCNRFFRDSA-N.