MM-11253

MM-11253 is a synthetic, conformationally restricted retinoid that acts as a selective antagonist of retinoic acid receptor gamma (RARgamma). It dose-dependently blocks the ability of RARgamma-selective agonists, but not retinoic acid (all-trans retinoic acid, Cay-11017), to inhibit the growth of oral squamous cell carcinoma cells in vitro.Formal Name: 6-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylic acid. CAS Number: 345952-44-5. Molecular Formula: C28H30O2S2. Formula Weight: 462.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 30 mg/ml. SMILES: CC(CCC1(C)C)(C)C2=C1C=C(C3(SCCS3)C4=CC(C=CC(C(O)=O)=C5)=C5C=C4)C=C2. InChi Code: InChI=1S/C28H30O2S2/c1-26(2)11-12-27(3,4)24-17-22(9-10-23(24)26)28(31-13-14-32-28)21-8-7-18-15-20(25(29)30)6-5-19(18)16-21/h5-10,15-17H,11-14H2,1-4H3,(H,29,30). InChi Key: DPVGXUNWCVEIGT-UHFFFAOYSA-N.