MLN-4760

Description: MLN-4760 is an angiotensin-converting (ACE2) inhibitor(human ACE2,IC50=0.44 nM). It also has excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 µM) and bovine carboxypeptidase A (CPDA, IC50, 27 µM). Target: RAAS. Smiles: CC(C)C[C@H](N[C@@H](Cc1cncn1Cc1cc(Cl)cc(Cl)c1)C(O)=O)C(O)=O. References: Dales NA, et al. Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors. J Am Chem Soc. 2002 Oct 9,124(40):11852-3.