ML162

Description: ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively). Target: GPX, Glutathione Peroxidase, Ferroptosis. Smiles: COc1ccc(cc1Cl)N(C(C(=O)NCCc1ccccc1)c1cccs1)C(=O)CCl. References: WeiWer M , Bittker J A , Lewis T A , et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS[J]. Bioorganic & Medicinal Chemistry Letters, 2012, 22(4):1822-1826.