ML RR-S2 CDA (ammonium salt)

ML RR-S2 CDA (ammonium salt)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay24106-500 500 µg -

6 - 10 Werktage*

133,00 €
Cay24106-1 1 mg -

6 - 10 Werktage*

225,00 €
 
ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical... mehr
Produktinformationen "ML RR-S2 CDA (ammonium salt)"
ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds and is an activator of stimulator of interferon genes (STING). It contains mixed linkages (ML) with both 2'5' and 3'5' linkages, which leads to increased thermal stability of human STING in a differential scanning fluorimetry (DSF) assay. ML RR-S2 CDA increases type I interferon production by THP-1 human monocytes relative to unmodified cyclic di-AMP (CDA, Cay-17753), indicating the ML enhances its action at human STING. It induces expression of IFN-beta and the pro-inflammatory cytokines TNF-alpha, IL-6, and Mcp-1 in murine bone marrow macrophages (BMM) isolated from wild-type, but not STING-/-, mice. ML RR-S2 CDA also induces IFN-beta expression in peripheral blood mononuclear cells (PBMCs) isolated from donors carrying STINGWT/WT, STINGWT/REF, and STINGWT/HAQ alleles. In vivo, ML RR-S2 CDA initiates tumor regression and prevents tumor growth upon tumor cell reimplantation in 4T1 murine mammary and CT26 murine colon cancer models.Formal Name: [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'->5')-adenosine, cyclic nucleotide, diammonium salt. CAS Number: 1638750-96-5. Synonyms: STING Inducer-1. Molecular Formula: C20H22N10O10P2S2 . 2NH4. Formula Weight: 724.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 15 mg/ml, Water: 12.5 mg/ml. SMILES: O[C@@H]([C@H](N1C=NC2=C(N)N=CN=C21)O3)[C@@](O[P@@]4([S-])=O)([H])[C@@]3([H])CO[P@](O[C@@]5([H])[C@H](N6C=NC7=C(N)N=CN=C76)O[C@@]([H])([C@]5(O)[H])CO4)([S-])=O.[NH4+].[NH4+]. InChi Code: InChI=1S/C20H24N10O10P2S2.2H3N/c21-15-9-17(25-3-23-15)29(5-27-9)19-12(32)13-8(38-19)2-36-42(34,44)40-14-11(31)7(1-35-41(33,43)39-13)37-20(14)30-6-28-10-16(22)24-4-26-18(10)30,,/h3-8,11-14,19-20,31-32H,1-2H2,(H,33,43)(H,34,44)(H2,21,23,25)(H2,22,24,26),2*1H3/t7-,8-,11-,12-,13-,14-,19-,20-,41-,42-,,/m1../s1. InChi Key: VZYXAGGQHVUTHM-ITQXCAEYSA-N.
Schlagworte: STING Inducer-1, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'->5')-adenosine, cyclic nucleotide, diammonium salt
Hersteller: Cayman Chemical
Hersteller-Nr: 24106

Eigenschaften

Anwendung: Synthetic cyclic dinucleotide (CDN), STING activator
MW: 724.6 D
Formel: C20H22N10O10P2S2 . 2NH4
Reinheit: >98%
Format: Solid

Datenbank Information

CAS : 1638750-96-5| Passende Produkte
KEGG ID : K12654 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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