ML-9 Free Base

Description: ML-9 (free base) suppresses MLCK, PKA, and PKC activity (Ki: 4, 32, and 54 µM, respectively). ML-9 (free base) is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) activity. ML-9 (free base) causes autophagy by stimulating autophagosome formation and inhibiting their degradation. Target: Others. Smiles: S(=O)(=O)(C=1C2=C(C(Cl)=CC=C2)C=CC1)N3CCCNCC3. References: Ito S, et al. ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis.Eur J Pharmacol. 2004 Feb 23,486(3):325-33.