ML-396

ML-396 is a positive allosteric modulator of group III metabotropic glutamate receptors (mGluRs) with EC50 values of 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively, in calcium mobilization assays. ML-396 potentiates LSP4-2022-induced reductions in paired-pulse field excitatory post synaptic potential (fEPSP) slopes in mouse hippocampal slices. In vivo, ML-396 (30 mg/kg) restores hippocampal long-term potentiation, improves novel object recognition, contextual fear learning, and social memory, and decreases sleep apneas in the Mecp2-/- mouse model of Rett syndrome.Formal Name: N-[3-chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide. CAS Number: 1630936-95-6. Synonyms: VU0422288. Molecular Formula: C17H11Cl2N3O2. Formula Weight: 360.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble, DMSO: slightly soluble. SMILES: O=C(NC1=CC(Cl)=C(OC2=CC=C(Cl)C=N2)C=C1)C3=CC=CC=N3. InChi Code: InChI=1S/C17H11Cl2N3O2/c18-11-4-7-16(21-10-11)24-15-6-5-12(9-13(15)19)22-17(23)14-3-1-2-8-20-14/h1-10H,(H,22,23). InChi Key: MZRLPXFGQKQHST-UHFFFAOYSA-N.