ML-365

ML-365 is a bis-amide TASK-1 potassium channel blocker (IC50 = 16 nM). It is selective for TASK-1 over TASK-3 channels in a QPatch assay (IC50 = 990 nM). It also acts as an antagonist of the metabotropic glutamate receptor mGluR5 (IC50 = 1.35 µM).Formal Name: 2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]-benzamide. CAS Number: 947914-18-3. Molecular Formula: C22H20N2O3. Formula Weight: 360.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 50 mg/ml, DMSO:PBS (pH 7.2)(1:5): 0.1 mg/ml, Ethanol: 1 mg/ml. lambdamax: 206, 268 nm. SMILES: CC1=CC=CC(C(NC2=CC=CC(NC(C3=C(OC)C=CC=C3)=O)=C2)=O)=C1. InChi Code: InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26). InChi Key: UTAJHKSGYJSZBR-UHFFFAOYSA-N.