ML-334

ML-334 is an inhibitor of the protein-protein interaction between the transcription factor Nrf2 and its inhibitor Keap1. It binds to the Keap1 Kelch domain (IC50 = 1 µM) to induce dissociation and nuclear translocation of Nrf2 and activation of the antioxidant response element (ARE) in a cell-based assay (EC50 = 12 µM).Formal Name: (1S,2R)-2-[[(1S )-1-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]-cyclohexanecarboxylic acid. CAS Number: 1432500-66-7. Synonyms: LH601. Molecular Formula: C26H26N2O5. Formula Weight: 446.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 40 mg/ml. SMILES: O=C([C@H]1[C@H](CCCC1)C(O)=O)N2CCC3=CC=CC=C3[C@H]2CN4C(C(C=CC=C5)=C5C4=O)=O. InChi Code: InChI=1S/C26H26N2O5/c29-23(20-11-5-6-12-21(20)26(32)33)27-14-13-16-7-1-2-8-17(16)22(27)15-28-24(30)18-9-3-4-10-19(18)25(28)31/h1-4,7-10,20-22H,5-6,11-15H2,(H,32,33)/t20-,21+,22-/m1/s1. InChi Key: LNENLABLFGGAFF-BHIFYINESA-N.