ML-230

ML-230 is an inhibitor of ATP-binding cassette family G member 2 (ABCG2). It selectively inhibits JC-1 efflux in Ig-MXP3 cells overexpressing ABCG2 over Jurkat cells overexpressing ABCB1 (IC50s = 0.13 and 4.65 µM, respectively). ML-230 enhances inhibition of IGROV-1/T8 ovarian cancer cell colony formation induced by topotecan (Cay-14129). Intratumoral injection of ML-230 (100 nM) and topotecan reduces tumor size in an IGROV-1/T8 mouse xenograft model.Formal Name: 3-furanyl[4-[5-(2-furanyl)-2-phenylpyrazolo[1,5-a]pyrimidin-7-yl]-1-piperazinyl]-methanone. CAS Number: 1776055-05-0. Synonyms: CID-44640177. Molecular Formula: C25H21N5O3. Formula Weight: 439.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 285, 296 nm. SMILES: O=C(N1CCN(CC1)C2=CC(C3=CC=CO3)=NC4=CC(C5=CC=CC=C5)=NN42)C6=COC=C6. InChi Code: InChI=1S/C25H21N5O3/c31-25(19-8-14-32-17-19)29-11-9-28(10-12-29)24-16-21(22-7-4-13-33-22)26-23-15-20(27-30(23)24)18-5-2-1-3-6-18/h1-8,13-17H,9-12H2. InChi Key: LRPGMVPQQLBMNE-UHFFFAOYSA-N.