ML 209

Description: ML-209 is an antagonist of retinoic acid receptor-related orphan receptor gammat (RORgammat, IC50= 1.1 µM in a reporter assay).1It inhibits RORgammat-induced transcription in HEK293T cells expressing the human receptor (IC50= 300 nM). ML-209 inhibits RORgammat-dependent differentiation of isolated na?ve cord blood human CD4+T cells into Th17 T helper cells. Target: ROR. Smiles: C(CC(=O)N1C[C@@H](C)C[C@@H](C)C1)(C2=C(OC)C=C(OC)C=C2O)C=3C=C4C(=CC3)OCO4. References: Huh, J.R., Englund, E.E., Wang, H., et al.Identification of potent and selective diphenylpropanamide RORgamma inhibitorsACS Med. Chem. Lett.4(1)79-84(2013)