MK 3118

Description: MK 3118, a glucan synthase inhibitor, is used potentially for the treatment of candida infection and aspergillosis. Target: Others. Smiles: C[C@@]12[C@]3([C@@](C=4[C@@]([C@]5(C)[C@@](C)(CC4)[C@H](C(O)=O)[C@]([C@@H](C(C)C)C)(C)CC5)(CC3)[H])(C[C@H]([C@@H]1OC[C@](C(C)(C)C)(C)N)N6C(=NC=N6)C=7C=CN=CC7)COC2)[H]. References: Lepak AJ, Marchillo K, Andes DR. Pharmacodynamic target evaluation of a novel oral glucan synthase inhibitor, SCY-078 (MK-3118), using an in vivo murine invasive candidiasis model. Antimicrob Agents Chemother. 2015 Feb,59(2):1265-72. doi: 10.1128/AAC.04445-14. PubMed PMID: 25512406, PubMed Central PMCID: PMC4335824.