Minoxidil

Minoxidil is a pyrimidine derivative that was originally developed as an anti-hypertensive agent and unexpectedly found to stimulate hair growth. Minoxidil directly affects arteriolar smooth muscle to decrease vascular resistance in part by opening ATP-sensitive potassium channels. It can activate cyclooxygenase 1 (AC50 = 80 µM), which is expressed in the dermal papilla of hair follicles, increasing prostaglandin E2 production in BALB/c 3T3 fibroblasts and human dermal papilla fibroblasts.Formal Name: 6-(1-piperidinyl)-2,4-pyrimidinediamine 3-oxide. CAS Number: 38304-91-5. Synonyms: Loniten, U-10858. Molecular Formula: C9H15N5O. Formula Weight: 209.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Ethanol: 1 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 231, 262, 284 nm. SMILES: NC1=[N+]([O-])C(N)=NC(N2CCCCC2)=C1. InChi Code: InChI=1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6H,1-5,10H2,(H2,11,12). InChi Key: ZFMITUMMTDLWHR-UHFFFAOYSA-N.