MG-132

Description: MG-132 (Z-Leu-Leu-Leu-al) is a cell-permeable, reversible 26S proteasome inhibitor (IC50=100 nM) that functions as an autophagy activator and induces apoptosis. Target: Apoptosis, Proteasome, Autophagy. Smiles: CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O. References: Han YH, et al. The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH. Oncol Rep. 2009 Jul,22(1):215-21.