Mevastatin

Mevastatin is a competitive HMG-CoA reductase inhibitor (Ki = 0.1 µM). In vivo, mevastatin (50 mg/kg) inhibits cholesterogenesis in the liver and ileum of normolipidemic rats, as well as enhances suppression of cholesterogenesis in cholesterol-fed rats or rats administered cholestyramine. Mevastatin also suppresses TNF-induced NF-kappaB activation (IC50 = ~17 µM) and potentiates apoptosis in human myeloid leukemia cells. It also suppresses induced ferroptosis in HT-1080 cells. Formulations containing mevastatin have been used in the treatment of familial hypercholesterolemia.Formal Name: 2S-methyl-(1S,2,3,7S,8S,8aR)-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2-H-pyran-2-yl]ethyl]-1-naphthalenyl ester-butanoic acid. CAS Number: 73573-88-3. Synonyms: Compactin, CS 500, L-637,312, ML 236B, NSC 281245, Statin I. Molecular Formula: C23H34O5. Formula Weight: 390.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 5 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 236 nm. SMILES: CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)C12. InChi Code: InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22?/m0/s1. InChi Key: AJLFOPYRIVGYMJ-DRHLORRRSA-N.