Methylspinazarin

Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT, IC50 = 0.8 µg/ml). It is selective for COMT over tyrosine hydroxylase, DOPA decarboxylase, and dopamine-beta-hydroxylase at 100 µg/ml. Methylspinazarin decreases blood pressure in spontaneously hypertensive rats when administered at a dose of 50 mg/kg.Formal Name: 2,3,5,8-tetrahydroxy-6-methyl-1,4-naphthalenedione. CAS Number: 41768-12-1. Synonyms: Methylspinazaline. Molecular Formula: C11H8O6. Formula Weight: 236.2. Purity: >95%. Formulation: (Request formulation change), A solid. SMILES: CC1=CC(O)=C(C(C(O)=C(O)C2=O)=O)C2=C1O. InChi Code: InChI=1S/C11H8O6/c1-3-2-4(12)5-6(7(3)13)9(15)11(17)10(16)8(5)14/h2,12-13,16-17H,1H3. InChi Key: WXLPYHMWBMMBOS-UHFFFAOYSA-N. Origin: Bacterium/Streptomyces sp..