Methylscopolamine (bromide)

Methylscopolamine is an antagonist of muscarinic acetylcholine receptors (Kds = 0.25, 0.37, 0.23, 0.22, and 0.3 nM for M1-5 respectively). It inhibits oxotremorine-induced gastric ulcer formation and pupillary light reflex in rats (ED50s = 0.4 and 3.6 µg/kg, respectively). It also increases pupil diameter in rats with an ED200 value of 1.8 µg/kg. Formulations containing methylscopolamine have been used for the treatment of peptic ulcers, intestinal spasms, and motion sickness.Formal Name: (1alpha,2beta,4beta,5alpha,7beta)-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane, monobromide. CAS Number: 155-41-9. Synonyms: NSC 61809, NSC 120606, U-5036. Molecular Formula: C18H24NO4 . Br. Formula Weight: 398.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(O[C@H]1C[C@H]([N+]2(C)C)[C@@H]3O[C@@H]3[C@H]2C1)[C@H](CO)C4=CC=CC=C4.[Br-]. InChi Code: InChI=1S/C18H24NO4.BrH/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11,/h3-7,12-17,20H,8-10H2,1-2H3,1H/q+1,/p-1/t12-,13-,14-,15+,16-,17+,/m1./s1. InChi Key: CXYRUNPLKGGUJF-RAFJPFSSSA-M.