Methyllycaconitine citrate

Description: Methyllycaconitine citrate (MLA) is an alpha7 neuronal nicotinic acetylcholine receptor (alpha7nAChR) antagonist that crosses the blood-brain barrier. Target: AChR. Smiles: OC(=O)CC(O)(CC(O)=O)C(O)=O.[H][C@]12C[C@]3([H])[C@]([H])([C@H]1OC)[C@](O)(C[C@@H]2OC)C1(O)[C@@H](OC)[C@@]2([H])C33C1N(CC)C[C@]2(COC(=O)c1ccccc1N1C(=O)C[C@H](C)C1=O)CC[C@@H]3OC. References: Zheng X, et al. Methyllycaconitine alleviates amyloid-beta peptides-induced cytotoxicity in SH-SY5Y cells. PLoS One. 2014 Oct 31,9(10):e111536.