Methylisothiazolinone

Methylisothiazolinone (MI) is an isothiazolinone-derived biocide. It is active against Gram-positive and Gram-negative bacteria, as well as fungi, when used in combination with methylchloroisothiazolinone (MCI) with MIC values of 0.0002, 0.0002, 0.00005, and 0.00005% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively. Methylisothiazolinone (50 µM) also inhibits c-Src autophosphorylation in a cell-free assay. It reduces cell viability percentage in isolated embryonic rat cortical neurons when used at a concentration of 3 µM and decreases neurite length at 1 µM. MI, alone and as a mixture with MCI, can elicit contact sensitization. Formulations containing methylisothiazolinone have been used in the control of bacteria, fungi, and algae in residential use and industry, as well as a preservative in personal care products.Formal Name: 2-methyl-3(2H)-isothiazolone. CAS Number: 2682-20-4. Synonyms: MI, MIT. Molecular Formula: C4H5NOS. Formula Weight: 115.2. Purity: >98%. Formulation: (Request formulation change), A 50% (w/v) aqueous solution. Solubility: Water: soluble. SMILES: CN1SC=CC1=O. InChi Code: InChI=1S/C4H5NOS/c1-5-4(6)2-3-7-5/h2-3H,1H3. InChi Key: BEGLCMHJXHIJLR-UHFFFAOYSA-N.