Methyl 4-hydroxycinnamate

Methyl 4-hydroxycinnamate is a phenol and derivative of p-coumaric acid (Cay-20929) that has been found in Allium cepa and has diverse biological activities. It scavenges DPPH (Cay-14805) radicals in a cell-free assay (IC50 = 772.47 µM). Methyl 4-hydroxycinnamate reduces LPS-induced nitric oxide (NO) production in RAW 264.7 cells (IC50 = 19.29 µM). It synergizes with curcumin (Cay-81025) to induce apoptosis in HL-60 acute myeloid leukemia cells when used at a concentration of 5 µM. Methyl 4-hydroxycinnamate (10, 30, and 60 mg/kg) reduces parasitemia and increases survival in P. berghei-infected mice.Formal Name: 3-(4-hydroxyphenyl)-2-propenoic acid, methyl ester. CAS Number: 19367-38-5. Synonyms: trans-4-Coumaric Acid methyl ester, trans-p-Coumaric Acid methyl ester, trans-para-Coumaric Acid methyl ester. Molecular Formula: C10H10O3. Formula Weight: 178.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml, DMSO: 15 mg/ml, Ethanol: 5 mg/ml. lambdamax: 229, 314 nm. SMILES: COC(/C=C/C1=CC=C(C=C1)O)=O. InChi Code: InChI=1S/C10H10O3/c1-13-10(12)7-4-8-2-5-9(11)6-3-8/h2-7,11H,1H3/b7-4+. InChi Key: NITWSHWHQAQBAW-QPJJXVBHSA-N. Origin: Synthetic.