Methiothepin (maleate)

Methiothepin is a non-selective antagonist of the serotonin (5-HT) receptor. It is a potent antagonist of 5-HT1A and 5-HT1B (IC50 = 16 nM and Ki = 0.2 nM, respectively) as well as 5-HT2A, 5-HT2B, and 5-HT2C receptors (Kis = 3.16, 2.08, and 4.46 nM, respectively). Methiothepin binds to 5-HT5A, 5-HT5B, 5-HT6, and 5-HT7 receptors with Kd values of 100, 15.8, 1.8, and 1 nM, respectively. It has been used to characterize the role of serotonin in various biological processes, including renal vasodilation and gastrointestinal function.Formal Name: 1-[10,11-dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methyl-piperazine, (2Z)-butenedioate. CAS Number: 19728-88-2. Synonyms: Metitepine. Molecular Formula: C20H24N2S2 . C4H4O4. Formula Weight: 472.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 276 nm. SMILES: CN(CC1)CCN1C2C3=C(C=CC(SC)=C3)SC4=CC=CC=C4C2.OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C20H24N2S2.C4H4O4/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20,5-3(6)1-2-4(7)8/h3-8,14,18H,9-13H2,1-2H3,1-2H,(H,5,6)(H,7,8)/b,2-1-. InChi Key: IWDBEHWZGDSFHR-BTJKTKAUSA-N.