Meglutol

Description: Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethyl glutaryl coenzyme A as well as inhibiting the activity of HYDROXYMET HYLGLUTARYL COA REDUCTASES which is the rate-limiting enzyme in the biosynthesis of cholesterol. Target: Endogenous Metabolite, HMG-CoA Reductase, Autophagy. Smiles: CC(O)(CC(O)=O)CC(O)=O. References: Santarelli F, et al. Ital J Pediatr. 2013 May 24,39:33.