MeBIO

MeBIO is a control analog of the GSK3alpha/beta inhibitor, BIO (Cay-13123). It displays minimal activity against Cdk1/Cyclin B, GSK3alpha/beta, and Cdk5/p25 (IC50s = 92.0, 44-100, and >100 µM, respectively). MeBIO has been identified as an aryl hydrocarbon receptor (AhR) agonist (EC50s = 20 and 93 nM for yeast and a hepatoma cell line, respectively) that causes AhR to translocate to the nucleus.Formal Name: (3Z)-6-bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-1-methyl-2H-indol-2-one. CAS Number: 667463-95-8. Synonyms: Me6BIO, 1-Methyl-6-bromo-indirubin-3'-oxime. Molecular Formula: C17H12BrN3O2. Formula Weight: 370.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Ethanol: Soluble. SMILES: O/N=C(C1=CC=CC=C1N2)/C2=C3C(N(C)C4=CC(Br)=CC=C4/3)=O. InChi Code: InChI=1S/C17H12BrN3O2/c1-21-13-8-9(18)6-7-11(13)14(17(21)22)16-15(20-23)10-4-2-3-5-12(10)19-16/h2-8,19,23H,1H3/b16-14-,20-15+. InChi Key: JUKQKURGZYNHFN-NVVUQHMZSA-N.