MDL 72527 (hydrochloride)

MDL 72527 is a polyamine oxidase (PAO) inhibitor that inhibits spermine oxidase and N1-acetylpolyamine oxidase (IC50s = 6.1 and 0.02 µM, respectively). It does not inhibit monoamine oxidase or D-amino acid oxidase. MDL 72527 inhibits PAO-dependent H2O2 production in vitro and in vivo and is used to study the role of PAO activity in diverse models, including infection, cancer, and hyperoxia.Formal Name: N1,N4-di-2,3-butadien-1-yl-1,4-butanediamine, dihydrochloride. CAS Number: 93565-01-6. Molecular Formula: C12H20N2 . 2HCl. Formula Weight: 265.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: slightly, DMSO: 0.33 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: C=C=CCNCCCCNCC=C=C. InChi Code: InChI=1S/C12H20N2/c1-3-5-9-13-11-7-8-12-14-10-6-4-2/h5-6,13-14H,1-2,7-12H2. InChi Key: IKSQCMLJDHRWOA-UHFFFAOYSA-N.