MD2-TLR4-I

MD2-TLR4-I is a toll-like receptor 4 (TLR4) antagonist. It inhibits LPS-induced production of TNF-alpha and IL-6 in primary mouse macrophages (IC50s = 0.89 and 0.53 µM, respectively). MD2-TLR4-I inhibits LPS-induced, TLR4-mediated NF-kappaB activation in a reporter assay using RAW 264.7 cells. In vivo, MD2-TLR4-I (10 mg/kg) reduces lung macrophage infiltration and prevents lung edema and alveolar thickening in a mouse model of LPS-induced acute lung injury.Formal Name: 2,6-dichloro-N-[3-(1H-indol-5-yl)-1H-indazol-5-yl]-benzamide. CAS Number: 2249801-12-3. Synonyms: Myeloid Differentiation Factor 2-Toll-like Receptor 4-I. Molecular Formula: C22H14Cl2N4O. Formula Weight: 421.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml. lambdamax: 242 nm. SMILES: O=C(C1=C(Cl)C=CC=C1Cl)NC2=CC3=C(NN=C3C4=CC5=C(NC=C5)C=C4)C=C2. InChi Code: InChI=1S/C22H14Cl2N4O/c23-16-2-1-3-17(24)20(16)22(29)26-14-5-7-19-15(11-14)21(28-27-19)13-4-6-18-12(10-13)8-9-25-18/h1-11,25H,(H,26,29)(H,27,28). InChi Key: AZPDJGLJPDRCDQ-UHFFFAOYSA-N.