Mca-DEVDAP-K(Dnp)-OH

Mca-DEVDAP-K(Dnp)-OH is a substrate for caspase-3. Upon cleavage by caspase-3, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify caspase-3 activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.Formal Name: N-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-alpha-aspartyl-L-alpha-glutamyl-L-valyl-L-alpha-aspartyl-L-alanyl-L-prolyl-N6-(2,4-dinitrophenyl)-L-lysine. CAS Number: 189696-20-6. Synonyms: Caspase-3 Fluorogenic Substrate III, CPP32 Fluorogenic Substrate III, 7-Methoxycoumarin-4-acetyl-DEVDAPK(Dnp)-OH, Mca-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-OH. Molecular Formula: C50H62N10O22. Formula Weight: 1155.1. Purity: >95%. Emission: 420 nm. Excitation: 328 nm. Formulation: (Request formulation change), A lyophilized powder. Solubility: Formic Acid: 1 mg/ml. SMILES: COC1=CC=C(C(CC(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N2CCC[C@H]2C(N[C@@H](CCCCNC3=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C3)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=CC(O4)=O)C4=C1. InChi Code: InChI=1S/C50H62N10O22/c1-24(2)43(57-44(69)31(14-15-39(62)63)54-46(71)33(22-40(64)65)53-38(61)18-26-19-42(68)82-37-21-28(81-4)11-12-29(26)37)48(73)56-34(23-41(66)67)45(70)52-25(3)49(74)58-17-7-9-35(58)47(72)55-32(50(75)76)8-5-6-16-51-30-13-10-27(59(77)78)20-36(30)60(79)80/h10-13,19-21,24-25,31-35,43,51H,5-9,14-18,22-23H2,1-4H3,(H,52,70)(H,53,61)(H,54,71)(H,55,72)(H,56,73)(H,57,69)(H,62,63)(H,64,65)(H,66,67)(H,75,76)/t25-,31-,32-,33-,34-,35-,43-/m0/s1. InChi Key: YOUVSUDOGAVRQX-AEAFXXELSA-N.