MC70

MC70 is a P-glycoprotein (P-gp) inhibitor. It inhibits the efflux of [3H]vinblastine by ATP binding cassette subfamily B member 1 (ABCB1) in Caco-2 colon cancer cells (EC50 = 0.05 µM). MC70 also inhibits the efflux of rhodamine-123 (Cay-16672) and calcein-AM (Cay-14948) by breast cancer resistant protein (BCRP) and multidrug resistance-associated protein 1 (MRP1) in MDCK cells (EC50s = 73 and 9.3 µM, respectively). MC70 (2 or 20 µM) enhances growth inhibition of adriamycin and doxorubicin-resistant (ADR) MCF-7/ADR breast cancer cells when used in combination with doxorubicin (Cay-15007), but does not alter the effectiveness of doxorubicin on growth inhibition in Caco-2 cells. It increases phosphorylation of p38 and JNK in Caco-2 cells and MCF-7/ADR cells when used at a concentration of 20 µM.Formal Name: 4'-[(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)methyl]-[1,1'-biphenyl]-4-ol. CAS Number: 1031367-64-2. Molecular Formula: C24H25NO3. Formula Weight: 375.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: :, DMSO: soluble. lambdamax: 281 nm. SMILES: COC1=C(OC)C=C(CN(CC2=CC=C(C3=CC=C(O)C=C3)C=C2)CC4)C4=C1. InChi Code: InChI=1S/C24H25NO3/c1-27-23-13-20-11-12-25(16-21(20)14-24(23)28-2)15-17-3-5-18(6-4-17)19-7-9-22(26)10-8-19/h3-10,13-14,26H,11-12,15-16H2,1-2H3. InChi Key: ATYXTVKHMLAWBZ-UHFFFAOYSA-N.