MBQ-167

MBQ-167 is a dual inhibitor of Rac and cell division cycle 42 (Cdc42, IC50s = 103 and 78 nM, respectively). It reduces Rac and Cdc42 GTP binding and GTPase activity and limits migration and mammosphere formation in MDA-MB-231 breast cancer cells when used at a concentration of 250 nM. MBQ-167 (250 nM), alone and in combination with the kinase inhibitor lapatinib (Cay-11493), reduces cell viability and induces apoptosis in lapatinib-resistant SK-BR-3 and MDA-MB-435 breast cancer cells. It also reduces growth rates, axial budding, and Cdc42 activity in S. cerevisiae when used at a concentration of 200 µM. Intraperitoneal administration of MBQ-167 (1 or 10 mg/kg three times per week) reduces tumor growth in an MDA-MB-435 mouse xenograft model.Formal Name: 9-ethyl-3-(5-phenyl-1H-1,2,3-triazol-1-yl)-9H-carbazole. CAS Number: 2097938-73-1. Molecular Formula: C22H18N4. Formula Weight: 338.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: CCN1C2=CC=CC=C2C3=CC(N4N=NC=C4C5=CC=CC=C5)=CC=C31. InChi Code: InChI=1S/C22H18N4/c1-2-25-20-11-7-6-10-18(20)19-14-17(12-13-21(19)25)26-22(15-23-24-26)16-8-4-3-5-9-16/h3-15H,2H2,1H3. InChi Key: LJCANTASZGYJLG-UHFFFAOYSA-N.