Maslinic Acid

Maslinic acid is found in a number of natural sources, most notably pomace olive oil (orujo). This pentacyclic triterpene has an antiproliferative effect against Caco-2 cancer cells (EC50 = 15 µM), HT-29 human colon cancer cells (EC50 = 74 µM), 1321N1 astrocytoma cells (IC50 = 25 µM), and human leukemia (CCRF-CEM and CEM/ADR5000) cells (IC50 = 7 µM and 9 µM respectively).{15043, 15044, 15046, 15045} Maslinic acid's antiproliferative activity likely comes from the induction of an oxidative apoptotic pathway, causing cell cycle and cytoskeleton alterations. Maslinic acid has been found to attenuate intracellular oxidative stress via inhibition of NO and H2O2 production and reduction of pro-inflammatory cytokine generation in murine macrophages. Recently maslinic acid has been found to inhibit the spread of the HIV virus by inhibiting the replication of a primary HIV-1 isolate as well as decreased the cytopathic effect and p24 antigen levels in MT2 cells.Formal Name: 2alpha,3beta-dihydroxy-olean-12-en-28-oic acid. CAS Number: 4373-41-5. Synonyms: Crategolic Acid, 2alpha-Hydroxyoleanoic Acid. Molecular Formula: C30H48O4. Formula Weight: 472.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 20 mg/ml, DMSO: PBS (pH 7.2)(1:2): 0.3 mg/ml, Ethanol: 0.5 mg/ml. SMILES: CC1(C)CC[C@]2(C(O)=O)CC[C@@]3(C)[C@]4(C)CCC5C(C)(C)[C@@H](O)[C@H](O)C[C@]5(C)[C@@]4([H])CC=C3[C@@]2([H])C1. InChi Code: InChI=1S/C30H48O4/c1-25(2)12-14-30(24(33)34)15-13-28(6)18(19(30)16-25)8-9-22-27(5)17-20(31)23(32)26(3,4)21(27)10-11-29(22,28)7/h8,19-23,31-32H,9-17H2,1-7H3,(H,33,34)/t19-,20-,21?,22-,23+,27+,28-,29-,30?/m1/s1. InChi Key: MDZKJHQSJHYOHJ-UKSPDLIDSA-N.