Mangiferin

Mangiferin is a xanthone glucoside that has been found in M. indica with diverse biological activities. It increases survival of HIV-1-infected MT-2 human leukemia cells (EC50 = 3.59 µg/ml). In an ascitic fibrosarcoma (AFS) mouse xenograft model, mangiferin (10 µg/g) inhibits tumor growth by 47% at 15 days post inoculation and increases lifespan by 38% relative to control. Mangiferin (50 mg/kg, p.o.) reduces the production of hydrogen peroxide induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014) in mouse peritoneal macrophages by 40% ex vivo. It also decreases TPA-induced DNA fragmentation in mouse liver and brain by 35 and 22%, respectively. Mangiferin (0.25-2 mg/kg, i.p.) dose-dependently increases survival of gamma-irradiated mice. Mangiferin (10 mg/kg, i.p.) reduces fasting plasma glucose, total cholesterol, triglycerides, and LDL cholesterol (LDL-C) levels in a rat model of diabetes induced by streptozotocin (Cay-13104) by 50, 57, 38.5, and 70%, respectively.Formal Name: 2-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one. CAS Number: 4773-96-0. Synonyms: NSC 248870. Molecular Formula: C19H18O11. Formula Weight: 422.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 5 mg/ml, Ethanol: slightly soluble. lambdamax: 242, 258, 316, 364 nm. SMILES: OC1=C(O)C=C(OC(C=C(O)C([C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)=C3O)=C3C4=O)C4=C1. InChi Code: InChI=1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11-,15-,17+,18-,19+/m1/s1. InChi Key: AEDDIBAIWPIIBD-ZJKJAXBQSA-N. Origin: Plant/Mangifera indica L..