M8-B (hydrochloride)

M8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin (Cay-10137), or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively). It displays no effect at other TRP channels. M8-B decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 KO mice.Formal Name: N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide, monohydrochloride. CAS Number: 883976-12-3. Molecular Formula: C22H24N2O3S . HCl. Formula Weight: 433.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 15 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 235, 276 nm. SMILES: COC(C=C(CN(C(C1=CC=CS1)=O)CCN)C=C2)=C2OCC3=CC=CC=C3.Cl. InChi Code: InChI=1S/C22H24N2O3S.ClH/c1-26-20-14-18(9-10-19(20)27-16-17-6-3-2-4-7-17)15-24(12-11-23)22(25)21-8-5-13-28-21,/h2-10,13-14H,11-12,15-16,23H2,1H3,1H. InChi Key: FMQJBHACRTZLME-UHFFFAOYSA-N.