LY3381916

LY3381916 is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1). It binds to apo-IDO1, which lacks heme, but does not inhibit mature heme-bound IDO1.Formal Name: N-[(1R)-1-[2,3-dihydro-1-[(tetrahydro-2H-pyran-4-yl)carbonyl]-1H-indol-5-yl]ethyl]-4-fluoro-benzamide. CAS Number: 2166616-75-5. Synonyms: IDO1-IN-5. Molecular Formula: C23H25FN2O3. Formula Weight: 396.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml. lambdamax: 260 nm. SMILES: O=C(C1CCOCC1)N2C3=CC=C([C@@H](C)NC(C4=CC=C(C=C4)F)=O)C=C3CC2. InChi Code: InChI=1S/C23H25FN2O3/c1-15(25-22(27)16-2-5-20(24)6-3-16)18-4-7-21-19(14-18)8-11-26(21)23(28)17-9-12-29-13-10-17/h2-7,14-15,17H,8-13H2,1H3,(H,25,27)/t15-/m1/s1. InChi Key: NUBWFWVVKLRSHS-OAHLLOKOSA-N.