LY2955303

LY2955303 is a potent antagonist of retinoic acid receptor gamma (RARgamma, Ki = 1.1 nM). It is selective for RARgamma over RARalpha and RARbeta (Kis = >1,700 and >2,980 nM, respectively). LY2955303 reduces differential weight bearing between the contralateral and ipsilateral limbs in a rat model of monoiodoacetate-induced osteoarthritis (ED50 = 0.72 mg/kg).Formal Name: 4-[5-[3,5-bis(1,1-dimethylethyl)phenyl]-1-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-1H-pyrazol-3-yl]-benzoic acid. CAS Number: 1433497-19-8. Molecular Formula: C36H42N4O3. Formula Weight: 578.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 25 mg/ml. lambdamax: 285 nm. SMILES: CN1CCN(C(C2=CC=C(N3C(C4=CC(C(C)(C)C)=CC(C(C)(C)C)=C4)=CC(C5=CC=C(C(O)=O)C=C5)=N3)C=C2)=O)CC1. InChi Code: InChI=1S/C36H42N4O3/c1-35(2,3)28-20-27(21-29(22-28)36(4,5)6)32-23-31(24-8-10-26(11-9-24)34(42)43)37-40(32)30-14-12-25(13-15-30)33(41)39-18-16-38(7)17-19-39/h8-15,20-23H,16-19H2,1-7H3,(H,42,43). InChi Key: YVXYHNKIOFSFMZ-UHFFFAOYSA-N.