LY294002

Description: LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kalpha, PI3Kdelta, and PI3Kbeta (IC50=0.5/0.57/0.97 µM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 µM) and an inhibitor of CK2 (IC50=98 nM). LY294002 activates apoptosis and autophagy. Target: PI3K, Autophagy, Apoptosis, Casein Kinase, DNA-PK. Smiles: O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1. References: Mao Y, et al. Regulation of cell apoptosis and proliferation in pancreatic cancer through PI3K/Akt pathway via Polo-like kinase Oncol Rep. 2016 Jul,36(1):49-56.