LY2828360

Description: LY2828360 is a cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). It selectively activates CB2 over CB1 in a GTPgammaS binding assay (EC50s = 20.1 and >100,000 nM, respectively). Target: Cannabinoid Receptor. Smiles: CN1CCN(CC1)c1nc(C)nc2n(C3CCOCC3)c(nc12)-c1ccccc1Cl. References: Lin X , Dhopeshwarkar A S , Huibregtse M , et al. The slowly signaling G protein-biased CB2 cannabinoid receptor agonist LY2828360 suppresses neuropathic pain with sustained efficacy and attenuates morphine tolerance and dependence[J]. Molecular Pharmacology, 2017:mol.117.109355.