LY2811376

Description: LY2811376, an orally available non-peptidic beta-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Abeta secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including pepsin, cathepsin D, or renin. Target: Beta-Secretase, BACE, Beta Amyloid. Smiles: C[C@]1(CCSC(N)=N1)c1cc(c(F)cc1F)-c1cncnc1. References: May P, et al. J Neurosci, 2011, 31(46), 16507-16516.