LY2608204

LY2608204 is an activator of glucokinase (GK, EC50 = 42 nM). It stimulates glucose metabolism in INS-1E rat insulinoma cells (mean EC50 = 579 nM). LY2608204 (30 mg/kg) decreases plasma glucose levels in a dose-dependent manner in fasted rats.Formal Name: (1R,2S)-2-cyclohexyl-1-[4-(cyclopropylsulfonyl)phenyl]-N-[5-[[2-(1-pyrrolidinyl)ethyl]thio]-2-thiazolyl]-cyclopropanecarboxamide. CAS Number: 1234703-40-2. Molecular Formula: C28H37N3O3S3. Formula Weight: 559.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMF:PBS(pH7.2) (1:2): 0.33 mg/ml, DMSO: 25 mg/ml. lambdamax: 232, 285 nm. SMILES: O=S(C1=CC=C([C@]2(C[C@H]2C3CCCCC3)C(NC4=NC=C(SCCN5CCCC5)S4)=O)C=C1)(C6CC6)=O. InChi Code: InChI=1S/C28H37N3O3S3/c32-26(30-27-29-19-25(36-27)35-17-16-31-14-4-5-15-31)28(18-24(28)20-6-2-1-3-7-20)21-8-10-22(11-9-21)37(33,34)23-12-13-23/h8-11,19-20,23-24H,1-7,12-18H2,(H,29,30,32)/t24-,28-/m0/s1. InChi Key: QIIVJLHCZUTGSD-CUBQBAPOSA-N.