LY2365109 (hydrochloride)

LY2365109 is an inhibitor of glycine transporter 1a (GlyT1a, IC50 = 15.8 nM in BE2-C cells expressing the human transporter). It is selective for GlyT1a over GlyT2 (IC50 = >30 µM in RD cells expressing the human transporter). LY2365109 (10 mg/kg) induces locomotor hyperactivity, impaired gait, compulsive walking, and labored breathing, as well as impairs the ability to stand, in rats. It also prevents maximal electroshock-induced acute seizures in mice and decreases the number of seizures in an electroshock-induced rat model of chronic epilepsy when administered at doses of 30 and 10 mg/kg, respectively.Formal Name: N-[2-[4-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methyl-glycine, monohydrochloride. CAS Number: 1779796-27-8. Molecular Formula: C22H27NO5 . HCl. Formula Weight: 421.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble. SMILES: O=C(CN(CCOC1=CC=C(C2=CC3=C(OCO3)C=C2)C=C1C(C)(C)C)C)O.Cl. InChi Code: InChI=1S/C22H27NO5.ClH/c1-22(2,3)17-11-15(16-6-8-19-20(12-16)28-14-27-19)5-7-18(17)26-10-9-23(4)13-21(24)25,/h5-8,11-12H,9-10,13-14H2,1-4H3,(H,24,25),1H. InChi Key: ZQVOAGQZHDAFRM-UHFFFAOYSA-N.